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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11878 | LRRK2 inhibitor 1 | LRRK2 , CDK | |
LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM. | |||
T2246 | LRRK2-IN-1 | Apoptosis , LRRK2 , CDK | |
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor. | |||
T39202 | CZC-54252 hydrochloride | LRRK2 | |
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human... | |||
T5184 | ERK5-IN-1 | ERK | |
ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM). | |||
T2022 | CZC-54252 | CZC54252,CZC 54252 | LRRK2 |
CZC-54252 is a potent inhibitor of LRRK2. | |||
T73846 | PF-06456384 trihydrochloride | ||
PF-06447475 trihydrochloride is a potent, selective LRRK2 kinase inhibitor that demonstrates excellent brain penetration, exhibiting IC50 values of 3 nM for wild-type LRRK2 and 11 nM for G2019S LRRK2 variants. It holds p... | |||
T79746 | LRRK2-IN-10 | LRRK2 | |
LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2 pS935 and 5.2 nM for G2019S-LRRK2 pS1292. It holds promise for... | |||
T81785 | MK-1468 | LRRK2 | |
MK-1468, a highly selective and brain-penetrant LRRK2 inhibitor, exhibits an IC50 of 0.8 nM and is utilized in the study of Parkinson's disease [1]. | |||
T61527 | GSK2646264 | ||
GSK2646264 (Compound 44) is a highly effective and specific inhibitor of spleen tyrosine kinase (SYK) with a pIC50 of 7.1. In addition to targeting SYK, GSK2646264 also inhibits several other kinases, including LCK, LRRK... |